I'm sorry to hear you had this misery with irritation after your first shot, but I'm glad you found this community. Welcome! Many people comment that it is the Betadine which is used as an antiseptic before the shot, which causes them problems afterwards. They ask for extra rinsing after the injection to remove as much Betadine as possible. Some community members also report that they use lubricating drops at home to ease this irritation. But these drops should only be used with the doctor's approval, because there is always a risk of infection after these injections. For that reason, some community members use sterile, single-use drops. But it is a matter for your doctor. Can you contact him/her before your next injection to let them know about the discomfort you experienced this time? Wendy, Patient Leader.