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Syfovre or Izerva

I know both are new and Izerva is the more recent.

But which is better? I really don't want the answer as provided by my doctor that they are similar and it doesn't matter which is used. At some point there should be sufficient data for this to be answered.

I know Syfovre and Izerva block the proteins C3 and C5 respectively - but which is more effective. OR ... and no one at the retina office wanted to respond to my question, why not use both on alternate months?

In the end, these will not help me. I lost the center of the left eye many years ago, and I am now rapidly losing the center of the right eye.

  1. i recently chose Izervay over Syfovre for 2 reasons. Izervay can be given with a smaller needle making it less painful. The second reason is one rare side effect shown with Syfovre and as yet not with Izervay. I thought this article might be helpful to you. https://www.nei.nih.gov/about/news-and-events/news/story-discovery-nei-funded-research-paves-way-new-dry-amd-drugs. Have you visited a low vision clinic? There are many aids available for those of us with low vision. Regards, Sharon Moore patient leader

    1. @Brown Eyed Girl, - I met with my retinal specialist this week - I see him every 3 months- and we discussed both drugs. He had a number of patients who had chosen to receive Syfovre but he stopped giving injections pretty early on when the adverse side effects, for this larger population became apparent. On to Izervay. He felt that the studies completed on this drug were not designed well (he also does research) and therefore the results could not be assessed. I was involved with medical research in my past and trust his judgement. Therefore, I have chosen not to get this drug.

      1. thanks for the update. Having trust in your retinal specialist is essential. I feel the same way about my doctor. Regards, Sharon Moore patient leader


    2. @Brown Eyed Girl

      Thanks for the comment, Wendy. I just wanted to share my experience, not try to influence. Researchers all have different goals and different thoughts on the important factors to include in their studies. The more eyes on a problem to be solved, the better! Trust in your own doctor is critical and as long as each of us has that, we will be comfortable with the decisions we make. I wish there was a 'magic bullet', but alas...that's not how things work!

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