Switching to hydroxychloroquine from sulfasalazine can indeed raise concerns about retinal side effects, as hydroxychloroquine is known to potentially impact the retina, leading to macular degeneration in some cases. It's crucial to discuss these risks with your rheumatologist and ensure regular eye check-ups to monitor any changes. Many patients use hydroxychloroquine successfully under careful supervision, so getting personalized advice and establishing a monitoring plan can help manage your concerns effectively.