that is a very good question! I'm not a medical person, but just from discussions in this group I know that there are many variables. Some people catch the wet amd early and may have better results than those who catch it later. Some people have to start on a less expensive drug for insurance purposes and then can move on to another drug if necessary. The next drug may or may not work better. I know there are different sub-types of macular degeneration, but I'm not qualified to discuss those. Some people can have the interval between shots extended enormously, and others seem to need them more often. These aren't answers to your question, unfortunately. I'm just agreeing with you. The variations are enormous. And this is not to mention that some people get scarring and others do not. I think this just reinforces the fact that we need a very experienced Retinal Specialist to help us. Perhaps the interval between your shots with Vabysmo might eventually increase. I hope so! Warm wishes, Wendy, Patient Leader.