thanks for your question. It's a good one! Some people do have irritation from the Betadine, but not everyone. Many community members ask if the strength of the Betadine can be reduced. Many also ask for extra rinses after the injection to wash out the Betadine. Perhaps your doctor will do this for you. I have heard Community members say their doctor uses an alternative antiseptic and I've heard others say that their doctor won't use anything except Betadine. Can you phone the surgery and discuss with them? Please let us know if the doctor comments about any alternative to Betadine. Best wishes, Wendy, Advocate.