What Is Beovu® (brolucizumab)?

There are two kinds of age-related macular degeneration (AMD): dry AMD, in which light-sensitive photoreceptors and supporting retinal pigment cells in the macula break down; and wet AMD, in which abnormal blood vessels grow under the retina that can leak or bleed, causing damage. This abnormal blood vessel growth can also be seen in myopic macular degeneration (MMD).¹

Though AMD is not curable, there are treatments to help slow progression of the disease and preserve existing vision.²

What is anti-VEGF therapy?

One of these treatments involves eye injections with medications known as anti-VEGF drugs. Anti-VEGF drugs bind or trap VEGF, which is a protein that stimulates the growth of blood vessels. When VEGF is produced in the eyes, it not only promotes the growth of new blood vessels, but these vessels tend to be abnormally weak and prone to leakage, which can cause damage to the retina and loss of vision.³

There are several anti-VEGF drugs. One of these is called Beovu® (brolucizumab).

How Beovu works

Beovu is given as an intravitreal injection, which means it is an injection directly into the eye, that must be done by a doctor. Beovu specifically binds to several forms of VEGF and helps to not only slow blood vessel growth, but also helps to stop the development and growth of new abnormal blood vessels, and prevent leakage.⁴

What are possible side effects of Beovu?

Side effects can happen with any medication, and Beovu is no different. Eye injections, including Beovu, have been associated with endophthalmitis (itching and inflammation of the fluids in the eye) and retinal detachment. The medication has also been associated with increased intraocular pressure, stroke, nonfatal heart attack, and vascular death.⁴

In clinical trials, common side effects of Beovu included:⁴

• Blurry vision
• Eye pain
• Conjunctival floaters
• Corneal abrasion
• Hypersensitivity
• Abnormal sensations in the eye
• Cataracts
• Increased tears

These are not all the possible side effects of Beovu. Talk to your doctor about what to expect when taking Beovu. You also should call your doctor if you have any changes that concern you when taking Beovu.

Other possible risks

There are no reliable studies of Beovu use in pregnant or lactating people. If you are pregnant or nursing, talk with your doctor about the possible risks. Beovu may pose a risk to a developing fetus and may be transferred in breast milk. Do not breastfeed while on Beovu or for 1 month after treatment is stopped.⁴

This drug has not been studied for pediatric populations and should not be administered to children without further study.⁴

Before beginning treatment for macular degeneration, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.