Syfovre (pegcetacoplan)

Reviewed by: HU Medical Review Board | Last reviewed: December 2023 | Last updated: December 2023

Syfovre® (pegcetacoplan injection) is the first treatment approved by the US Food and Drug Administration (FDA) to treat adults with geographic atrophy (GA). Geographic atrophy is an advanced type of dry age-related macular degeneration (AMD) that affects about 1 million people in the United States. It is a chronic condition that can lead to loss of retinal function and vision loss.1,2

What are the ingredients in Syfovre?

The active ingredient in Syfovre is pegcetacoplan.3

How does Syfovre work?

Syfovre is a complement inhibitor that helps to slow the progression of GA. Complements are a vital part of the immune system. They help to detect, attack, and remove foreign pathogens, such as bacteria and viruses. But in people with GA, these complements are thought to be overactive and mistakenly attack healthy cells in the eye.2,4

Syfovre works by blocking a specific complement protein active in the eye, complement protein C3, helping to slow down the progression of damage to retinal cells over time.2,4

What are the possible side effects?

The most common side effects of Syfovre are:3

  • Eye discomfort
  • Wet AMD
  • Specks floating in your vision
  • Bleeding in the white part of the eye

These are not all the possible side effects of Syfovre. Talk to your doctor about what to expect when taking Syfovre. You also should call your doctor if you have any changes that concern you when taking Syfovre.

Other things to know

Syfovre is an injection that is given by a doctor into the eye. This is called an intravitreal injection. After an injection of Syfovre, your eyesight might be temporarily impaired. Do not drive or operate machinery until your vision returns to normal. Syforvre is given once every 25 to 60 days.1,3

You should not be treated with Syfovre if you have an active eye infection or have any swelling, pain, or redness in or around your eye.3

Tell your doctor if you have a history of any of the following:3

  • Seeing flashes of light
  • Specks in your vision
  • High pressure in the eye
  • Glaucoma

There is not enough data to know whether Syfovre is safe to take while pregnant or breastfeeding. Before receiving Syfovre, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.3

Before beginning treatment for geographic atrophy, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Syfovre.

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