Eylea/Eylea HD (aflibercept)?

Eylea^® and Eyleasup>® HD (aflibercept) are prescription drugs approved to treat wet age-related macular degeneration (AMD). They are a type of drug known as a vascular endothelial growth factor (VEGF) inhibitor.^1,2

Eylea and Eylea are given as an injection into the eye (intravitreal injection). The recommended treatment schedule may vary:^1,2

• Eylea – An injection every 4 weeks for the first 3 months, followed by an injection every 4 to 12 weeks
• Eylea HD – An injection every 4 weeks for the first 3 months, followed by an injection every 8 to 16 weeks

Your doctor will monitor your vision during treatment and develop an injection schedule that is right for you.^1,2

What is anti-VEGF therapy?

VEGF is a protein that promotes the growth of new blood vessels. People with wet AMD have too much VEGF in their eye. This leads to abnormal growth of weak, leaky blood vessels that affect vision.³

Blocking the VEGF protein reduces the growth of weak, leaky blood vessels in people with MD. This can slow the progression of wet AMD.³

How do Eylea and Eylea HD work?

Eylea and Eylea HD bind to VEGF, which helps slow blood vessel growth. This also helps stop the growth of new abnormal blood vessels and prevent weak, leaky blood vessels. This process helps to preserve your existing vision and slow the progression of wet AMD.^1,2

What are the possible side effects of Eylea and Eylea HD?

The most common side effects of Eylea and Eylea HD include:^1,2

• Bursting of small blood vessels just beneath the clear surface of the eye (conjunctival hemorrhage)
• Bleeding in the retina (retinal hemorrhage)
• Cataracts
• Eye pain
• Floaters
• Increased eye pressure

These are not all the possible side effects of Eylea and Eylea HD. Talk to your doctor about what to expect when taking Eylea or Eylea HD. You also should call your doctor if you have any changes that concern you when taking Eylea or Eylea HD.

Other things to know

Before starting treatment with Eylea or Eylea HD, tell your doctor if you have:^1,2

• An eye infection
• Eye pain
• Eye redness
• Blurry vision

Eylea and Eylea HD may harm an unborn baby. If you can become pregnant, you should use birth control during treatment and for some time after the last dose of Eylea or Eylea HD. You should also not breastfeed during treatment with Eylea or Eylea HD and for some time after the last dose. Talk to your doctor about your options for birth control and breastfeeding while taking Eylea or Eylea HD.^1,2

Before beginning treatment for macular degeneration, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Eylea and Eylea HD.